One Pot Synthesis of Alpha-Aminonitrile and Alpha-Amino Acid From Schiff Bases

Authors

  • Behnaz Almasi Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516 Tehran, I.R. IRAN
  • Mohammad M. Hashemi Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516 Tehran, I.R. IRAN
Abstract:

Addition of Potassium cyanide to a mixture of Schiff base and lithium perchlorate afforded a-aminonitriles in high yields. Addition of potassium cyanide to a methanolic solution of Schiff base and phosphoric acid afforded a-aminonitriles. When the reaction mixture was refluxed it gave a-amino acids in high yields.

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one pot synthesis of alpha-aminonitrile and alpha-amino acid from schiff bases

addition of potassium cyanide to a mixture of schiff base and lithium perchlorate afforded a-aminonitriles in high yields. addition of potassium cyanide to a methanolic solution of schiff base and phosphoric acid afforded a-aminonitriles. when the reaction mixture was refluxed it gave a-amino acids in high yields.

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Journal title

volume 18  issue 1

pages  33- 35

publication date 1999-06-01

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